Depolarization inactivation of dopamine neurons: an artifact?
نویسندگان
چکیده
منابع مشابه
Depolarization inactivation of dopamine neurons: an artifact?
A widely accepted theory postulates that, in rats, chronic treatment with neuroleptics causes the depolarization inactivation of the majority of midbrain dopamine (DA) neurons. The present study was aimed to verify whether general anesthesia and/or other factors might contribute to the depolarization inactivation of A9 and A10 DA neurons. To investigate on the possible role played by DA recepto...
متن کاملMathematical analysis of depolarization block mediated by slow inactivation of fast sodium channels in midbrain dopamine neurons.
Dopamine neurons in freely moving rats often fire behaviorally relevant high-frequency bursts, but depolarization block limits the maximum steady firing rate of dopamine neurons in vitro to ∼10 Hz. Using a reduced model that faithfully reproduces the sodium current measured in these neurons, we show that adding an additional slow component of sodium channel inactivation, recently observed in th...
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Title: Mathematical analysis of depolarization block mediated by slow inactivation of 1 fast sodium channels in midbrain dopamine neurons 2 3 Authors names and affiliation: 4 Kun Qian , Na Yu, Kristal R Tucker , Edwin S Levitan 2 and Carmen C Canavier 1 5 1 Department of Cell Biology and Anatomy and Neuroscience Center of Excellence, 6 Louisiana State University School of Medicine, New Orleans,...
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Correlations between substantia nigra (SN) dopamine (DA) cell activity and striatal extracellular DA were examined using simultaneous extracellular single-unit recordings and in vivo microdialysis performed in drug-naive rats and in rats treated repeatedly with haloperidol (HAL). Intact rats treated with HAL for 21-28 d exhibited significantly fewer active DA cells, indicating the presence of d...
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Cell-gene therapy is a dynamic constituent of novel medical biotechnology. Neurodegenerative disordersin which damage to or demise of specific brain cell types plays central role, are clear examples of diseasecandidate for cell replacement therapy. Dopaminergic (DAergic) neurons biosynthesize dopamine, a vitalneurotransmitter in the central nervous system. Due to the involveme...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1995
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.15-02-01144.1995